Danchigai

Danchigai (だんちがい, lit. "Big Difference") is a Japanese four-panel comedy manga series by Kazusa Yoneda, serialized in Ichijinsha's seinen manga magazine Manga 4-Koma Palette since June 2011. The series received an anime adaptation, which aired from July to September 2015.

Plot
Haruki Nakano lives an average high school life, except for the fact that his mother is overseas and he shares an apartment with his four sisters. There's the oldest, Mutsuki, who has a bad habit of falling asleep in his bed, the junior high school student Yayoi, who hits him whenever something happens, and then the grade school twins, Uzuki and Satsuki, who love to play pranks on their older brother.

Why it Rocks
Great animation.

Cool stories.

Awesome characters especially for Uzuki and Satsuki.